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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > SGI-1027CAS：1020149-73-8
Molecular Formula：C27H23N7O
Molecular Weight：461.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light brown Solid
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| CAS | 1020149-73-8 |
| Name | SGI-1027 |
| Molecular Formula | C27H23N7O |
| Molecular Weight | 461.52 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to light brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD27937047 |
| SMILES | O=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3 |
| Target Point | DNA Methyltransferase |
| Passage | Epigenetics |
| Background | SGI-1027 is a DNMT inhibitor. |
| Biological Activity | SGI-1027 是 DNA 甲基转移酶 (DNMT) 抑制剂，对以 poly(dI-dC) 为底物的 DNMT3B，DNMT3A 和 DNMT1 的 IC50 值分别为 7.5 μM，8 μM 和 12.5 μM。[1-2] |
| Data Literature Source | [1]. Datta J，et al. A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 2009 May 15;69(10):4277-85. [2]. Rilova E，et al. Design，synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation. ChemMedChem. 2014 Mar;9(3):590-601 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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