| Gene Name |
TAP2 |
| Synonyms |
ABC transporter，MHC 2;ABC18;ABCB3;Antigen peptide transporter 2;APT2;ATP binding cassette，sub family B (MDR/TAP)，member 3;ATP-binding cassette sub-family B member 3;D6S217E;Peptide supply factor 2;Peptide transporter involved in antigen processing 2;Peptide transporter PSF2;Peptide transporter TAP2;PSF 2;PSF-2;PSF2;Really interesting new gene 11 protein;RING 11;RING11;TAP 2;Tap2;TAP2_HUMAN;Transporter 2 ATP binding cassette sub family B;Transporter 2，ABC (ATP binding cassette;Transporter 2，ATP binding cassette，sub family B (MDR/TAP); |
| English Name |
Recombinant human TAP2 protein |
| Full Name |
transporter 2，ATP-binding cassette，sub-family B (MDR/TAP) |
| Chinese Name |
转运蛋白2 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q03519 |
| Gene ID |
6891 |
| Reactivity |
Human Mouse Rat |
| Molecular Weight |
39kDa |
| Interval Range |
337-686aa |
| Background |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
No activity experimental data, to be verified. |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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