| Gene Name |
HSPB8 |
| Synonyms |
Alpha crystallin C chain;Alpha-crystallin C chain;Charcot Marie Tooth disease axonal type 2L;Charcot Marie Tooth disease spinal;CMT2L;CRYAC;DHMN 2;DHMN2;E2 induced gene 1 protein;E2-induced gene 1 protein;E2IG1;H11;Heat shock 22a protein 8;Heat shock 27a protein 8;Heat shock protein 22;Heat shock protein beta 8;Heat shock protein beta-8;Hereditary motor neuropathy distal;HMN 2;HMN2;HMN2A;HSB8;HSPB 8;HspB8;HSPB8_HUMAN;OTTHUMP00000239768;Protein kinase H11;Small stress protein like protein HSP22;Small stress protein-like protein HSP22;Spinal muscular atrophy distal adult autosomal dominant; |
| English Name |
Recombinant human HSPB8 protein |
| Full Name |
heat shock 22a protein 8 |
| Chinese Name |
热休克22a蛋白8 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q9UJY1 |
| Gene ID |
26353 |
| Reactivity |
Human Mouse Rat (Bovine Dog Monkey Orangutan) |
| Molecular Weight |
22kDa |
| Interval Range |
1-196aa |
| Background |
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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