| Gene Name |
HLA-DRB1 |
| Synonyms |
2B1F_HUMAN;DR1;DR16;DR5;DR8;DRB1;DRw10;DW2.2/DR2.2;FLJ75017;FLJ76359;HLA class II antigen beta chain;HLA class II histocompatibility antigen，DR-1 beta chain;HLA class II histocompatibility antigen，DRB1-15 beta chain;HLA-DR-beta 1;HLA-DR1B;HLA-DRB;HLA-DRB1;human leucocyte antigen DRB1;Leucocyte antigen DR beta 1 chain;leucocyte antigen DRB1;lymphocyte antigen DRB1;major histocompatibility complex，class II，DR beta 1;MHC class II antigen;MHC class II antigen DRB1*15;MHC class II antigen HLA-DR13;MHC class II HLA-DR beta 1 chain;MHC class II HLA-DR-beta cell surface glycoprotein;MHC class II HLA-DRw10-beta;SS1;HLA-DRB3; |
| English Name |
Recombinant human HLA-DRB1 protein |
| Full Name |
major histocompatibility complex，class II，DR beta 1 |
| Chinese Name |
主要组织相容性复合体II类DRβ1 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P01911 |
| Gene ID |
3123 |
| Reactivity |
Human |
| Molecular Weight |
30kDa |
| Interval Range |
1-266aa |
| Background |
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 a. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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