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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ClinofibrateCAS：30299-08-2
Molecular Formula：C28H36O6
Molecular Weight：468.58
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 30299-08-2 |
| Name | Clinofibrate |
| Molecular Formula | C28H36O6 |
| Molecular Weight | 468.58 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1312995-182-4 |
| MDL | MFCD00865769 |
| SMILES | CCC(OC1=CC=C(C2(C3=CC=C(OC(CC)(C)C(O)=O)C=C3)CCCCC2)C=C1)(C)C(O)=O |
| InChIKey | BMOVQUBVGICXQN-UHFFFAOYSA-N |
| InChI | InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32) |
| PubChem CID | 2787 |
| Target Point | HMG-CoA Reductase (HMGCR) |
| Passage | Metabolic Enzyme&Protease |
| Background | Clinofibrate inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR) (hydroxymethylglutaryl coenzyme A reductase), a lipid-lowering agent used to control high cholesterol and triglyceride levels in the blood. |
| Biological Activity | Clinofibrate (S-8527)是一种降血脂药和一种HMG-CoA还原酶抑制剂。[1-4] |
| Data Literature Source | [1]. Okazaki M，et al. Effects of clinofibrate on plasma fibrinogen level in high fructose diet-induced hyperlipidemic rats. In Vivo. 1994 Nov-Dec;8(6):1057-61. [2]. Shirai K，et al. Effect of clinofibrate on lipid metabolism of aorta in atherosclerotic rats. Artery. 1983;12(3):145-55. [3]. Suzuki K，et al. Effects of S-8527 (1，1-bis4'-(1'-carboxy'1'-methylpropoxy)-phenyl)-cyclohexane)，a new hypolipidemic compound，on triglyceride metablolism in rats. Biochem Pharmacol. 1975 Jun 15;24(11-12):1203-7. [4]. Suzuki K，et al. Hypolipidemic effect of a new aryloxy compound，S-8527，in experimental animals. Jpn J Pharmacol. 1974 Jun;24(3):407-14. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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