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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > GW-0742CAS：317318-84-6
Molecular Formula：C21H17F4NO3S2
Molecular Weight：471.49
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 317318-84-6 |
| Name | GW-0742 |
| Molecular Formula | C21H17F4NO3S2 |
| Molecular Weight | 471.49 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1532714-185-1 |
| MDL | MFCD07369423 |
| SMILES | O=C(O)COC1=CC=C(SCC2=C(C)N=C(C3=CC=C(C(F)(F)F)C(F)=C3)S2)C=C1C |
| Target Point | PPARδ |
| Passage | Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | GW-0742 is a potent and selective PPARβ/δ agonist. |
| Biological Activity | GW0742 是一种有效的 PPARβ 和 PPARδ 激动剂，对人 PPARδ 的 IC50 值为 1 nM，对人 PPARδ，PPARα 和 PPARγ 的 EC50 值分别为 1 nM，1.1 μM 和 2 μM。[1-4] |
| Data Literature Source | [1]. Sznaidman ML，et al. Novel selective small molecule agonists for peroxisome proliferator-activated receptor delta (PPARdelta)--synthesis and biological activity. Bioorg Med Chem Lett. 2003 May 5;13(9):1517-21. [2]. Smith SA，et al. Effect of the peroxisome proliferator-activated receptor beta activator GW0742 in rat cultured cerebellar granule neurons. J Neurosci Res. 2004 Jul 15;77(2):240-9. [3]. Galuppo M，et al. GW0742，a high affinity PPAR-β/δ agonist reduces lung inflammation induced by bleomycin instillation in mice. Int J Immunopathol Pharmacol. 2010 Oct-Dec;23(4):1033-46. [4]. Kuo SC，et al. Activation of receptors δ (PPARδ) by agonist (GW0742) may enhance lipid metabolism in heart both in vivo and in vitro. Horm Metab Res. 2013 Nov;45(12):880-6 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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