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Gemfibrozil

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Cat.No：IG2450 Solarbio

CAS：25812-30-0

Molecular Formula：C₁₅H₂₂O₃

Molecular Weight：250.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	25812-30-0
Name	Gemfibrozil
Molecular Formula	C₁₅H₂₂O₃
Molecular Weight	250.33
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 247-280-2
MDL	MFCD00079335
SMILES	O=C(O)C(C)(C)CCCOC1=CC(C)=CC=C1C
InChIKey	HEMJJKBWTPKOJG-UHFFFAOYSA-N
InChI	InChI=1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)
PubChem CID	3463
Target Point	PPARα
Passage	Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease
Background	It is a PPAR-α activator and a non-selective inhibitor of P450.
Biological Activity	Gemfibrozil 是一种 PPAR-α 激活剂，为一种降脂药；Gemfibrozil 同时是 P450 的非选择性抑制剂，对 CYP2C9，2C19，2C8 和 1A2 的 Ki 值分别为 5.8，24，69 和 82 μM。[1-3]
Data Literature Source	[1]. Pahan K，et al. Gemfibrozil，a lipid-lowering drug，inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem. 2002 Nov 29;277(48):45984-91. Epub 2002 Sep 18. [2]. Almad A，et al. The PPAR alpha agonist gemfibrozil is an ineffective treatment for spinal cord injured mice. Exp Neurol. 2011 Dec;232(2):309-17. [3]. Wang JS，et al. Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1352-6.
Unit	Bottle
Specification	50mg 100mg 250mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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