English Name |
Anti-MBTPS2 Polyclonal Antibody |
Chinese Name |
S2P内肽酶抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Predicted Reactivity |
Cow;Chimpanzee;Hamster |
Dilution Ratio |
IHC 1:100-300. |
Target |
MBTPS2 |
Synonyms |
BRESEK, Endopeptidase S2P, IFAP, KFSDX, MBTP2_HUMAN, MBTPS2, Membrane bound transcription factor site 2 protease, membrane-bound transcription factor peptidase, site 2, membrane-bound transcription factor protease, site 2, Membrane-bound transcription factor site-2 protease, S2P, S2P endopeptidase, Site 2 protease, SREBPs intramembrane protease, Sterol regulatory element-binding proteins intramembrane protease |
Background |
Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209, PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894). |
Swiss Prot |
O43462 |
Gene ID |
51360 |
Subcellular Location |
Cytoplasm |
Immunogen |
A synthetic peptide of human MBTPS2 |
Public Immunogen Range |
5-55/519aa |
Calculated MW |
57kDa |
Purification Method |
Affinity purification |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human Mouse |
Application |
IHC |