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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SR-3029CAS：1454585-06-8
Molecular Formula：C23H19F3N8O
Molecular Weight：480.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1454585-06-8 |
| Name | SR-3029 |
| Molecular Formula | C23H19F3N8O |
| Molecular Weight | 480.45 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30187527 |
| SMILES | FC1=CC(N2C=NC3=C(NCC4=NC5=CC=C(F)C(F)=C5N4)N=C(N6CCOCC6)N=C23)=CC=C1 |
| Target Point | Casein Kinase |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | SR-3029 is a potent, ATP-competitive inhibitor of CK1δ and CK1ε. |
| Biological Activity | SR-3029 is a potent and ATP competitive CK1δ and CK1ε inhibitor， with IC50s of 44 nM and 260 nM， respectively， and Kis of 97 nM for both kinases.[1-2] |
| Data Literature Source | [1]. Bibian M， et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80. [2]. Rosenberg LH， et al. Therapeutic targeting of casein kinase 1δ in breast cancer. Sci Transl Med. 2015 Dec 16;7(318):318ra202. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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