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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Bafilomycin A1CAS：88899-55-2
Molecular Formula：C35H58O9
Molecular Weight：622.83
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：White to yellow Solid
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| CAS | 88899-55-2 |
| Name | Bafilomycin A1 |
| Molecular Formula | C35H58O9 |
| Molecular Weight | 622.83 |
| Solubility | Soluble in DMSO |
| Purity | ≥95% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 621-324-4 |
| MDL | MFCD06795130 |
| SMILES | C[C@H]([C@](O[C@@H]1C(C)C)(C[C@@H](O)[C@@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C |
| Target Point | Proton Pump;H+-ATPase |
| Passage | Autophagy |
| Background | Bafilomycin A1 is a macrolide antibiotic and a specific， reversible V-ATPase inhibitor. Bafilomycin A1 is a late-stage inhibitor of autophagy， blocking the fusion of autophagosomes with lysosomes. Bafilomycin A1 also induces apoptosis. |
| Biological Activity | Bafilomycin A1，一种从链霉菌属物种中分离的大环内酯类抗生素，是特异的 vacuolar-type H+ ATPase 抑制剂。[1-4] |
| Data Literature Source | [1]. Yuan N，et al. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56. [2]. Lu X，et al. Bafilomycin A1 inhibits the growth and metastatic potential of the BEL-7402 liver cancer and HO-8910 ovarian cancer cell lines and induces alterations in their microRNA expression. Exp Ther Med. 2015 Nov;10(5):1829-1834. [3]. Ohkuma S，et al. Inhibition of cell growth by bafilomycin A1，a selective inhibitor of vacuolar H(+)-ATPase. In Vitro Cell Dev Biol Anim. 1993 Nov;29A(11):862-6. [4]. Ohta T，et al. Bafilomycin A1 induces apoptosis in the human pancreatic cancer cell line Capan-1. J Pathol. 1998 Jul;185(3):324-30. |
| Unit | Bottle |
| Specification | 25ug 100ug 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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