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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > A-438079 HydrochlorideCAS：899431-18-6
Molecular Formula：C13H10Cl3N5
Molecular Weight：342.61
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 899431-18-6 |
| Name | A-438079 Hydrochloride |
| Molecular Formula | C13H10Cl3N5 |
| Molecular Weight | 342.61 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-604-1 |
| MDL | MFCD09971142 |
| SMILES | ClC1=C(Cl)C(C2=NN=NN2CC3=CC=CN=C3)=CC=C1.[H]Cl |
| Target Point | P2X Receptor |
| Passage | Membrane Transporter&Ion Channel |
| Background | A-438079 Hydrochloride is a potent and selective P2X7 receptor antagonist. |
| Biological Activity | A 438079 (hydrochloride) is a potent， and selective P2X7 receptor antagonist[1] |
| Data Literature Source | [1]. McGaraughty S，et al. P2X7-related modulation of pathological nociception in rats. Neuroscience. 2007 Jun 8;146(4):1817-28. [2]. Mesuret G，et al. CNS Neurosci Ther. 2014 Jun;20(6):556-64. [3]. Marcellino D，et al. On the role of P2X(7) receptors in dopamine nerve cell degeneration in a rat model of Parkinson's disease: studies with the P2X(7) receptor antagonist A-438079. J Neural Transm (Vienna). 2010 Jun;117(6):681-7. [4]. Martins JP，et al. The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice. Br J Pharmacol. 2012 Jan;165(1):183-96. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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