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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > SilmitasertibCAS：1009820-21-6
Molecular Formula：C19H12ClN3O2
Molecular Weight：349.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1009820-21-6 |
| Name | Silmitasertib |
| Molecular Formula | C19H12ClN3O2 |
| Molecular Weight | 349.77 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD13184796 |
| SMILES | O=C(C1=CC=C2C(N=C(NC3=CC=CC(Cl)=C3)C4=C2C=NC=C4)=C1)O |
| Target Point | Casein Kinase |
| Passage | Cell Cycle;DNA Damage/DNA Repair; Stem Cells |
| Background | Silmitasertib is a potent and highly selective CK2 inhibitor. |
| Biological Activity | Silmitasertib (CX-4945)是有效的，选择性CK2(casein kinase 2)抑制剂，无细胞试验中IC50为1 nM,对 Flt3, Pim1 和 CDK1作用效果稍弱(细胞试验中没有活性)。Silmitasertib可诱导自噬并促进细胞凋亡。[1] |
| Data Literature Source | [1] Siddiqui-Jain A，et al. Cancer Res，2010，70(24)，10288-10298. [2] Pierre F，et al. J Med Chem，2011，54(2)，635-654. [3] Siddiqui-Jain A，et al. Mol Cancer Ther，2012，11(4)，994-1005. [4] Bliesath J，et al. Cancer Lett，2012，322(1)，113-118. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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