| Gene Name |
CHMP2A |
| Synonyms |
BC 2;BC2;Charged multivesicular body protein 2a;CHM2A_HUMAN;CHMP2;CHMP2a;Chromatin modifying protein 2a;Chromatin-modifying protein 2a;hVps2 1;hVps2-1;putative breast adenocarcinoma marker;Putative breast adenocarcinoma marker BC-2;Putative breast adenocarcinoma marker BC2;Vacuolar protein sorting associated protein 2 1;Vacuolar protein sorting-associated protein 2-1;Vps2 1;VPS2;Vps2-1;VPS2A; |
| English Name |
Recombinant human CHMP2A protein |
| Full Name |
chromatin modifying protein 2A |
| Chinese Name |
染色质修饰蛋白2A |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
O43633 |
| Gene ID |
27243 |
| Reactivity |
Human Mouse (Chicken) |
| Molecular Weight |
24kDa |
| Interval Range |
1-222aa |
| Background |
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes.ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966).Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712).ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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