| Gene Name |
UGCG |
| Synonyms |
GLCT-1;GCS; |
| English Name |
Recombinant human UGCG protein |
| Full Name |
UDP-glucose ceramide glucosyltransferase |
| Chinese Name |
UDP-葡萄糖神经酰胺葡萄糖基转移酶 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q16739 |
| Gene ID |
7357 |
| Reactivity |
Human Mouse Rat |
| Molecular Weight |
28kDa |
| Interval Range |
1-250aa |
| Background |
Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer.Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures.Glycosphingolipids are essential components of membrane microdomains that mediate membrane trafficking and signal transduction.They are implicated in many fundamental cellular processes, including growth, differentiation, migration, morphogenesis, cell-to-cell and cell-to-matrix interactions.They are required for instance in the proper development and functioning of the nervous system.As an example of their role in signal transduction, they regulate the leptin receptor/LEPR in the leptin-mediated signaling pathway.They also play an important role in the establishment of the skin barrier regulating keratinocyte differentiation and the proper assembly of the cornified envelope.The biosynthesis of GSLs is also required for the proper intestinal endocytic uptake of nutritional lipids (By similarity). |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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