Gene Name |
DKC1 |
Synonyms |
CBF5;CBF5 homolog;Cbf5p homolog;DKC 1;DKC;Dkc1;DKC1_HUMAN;DKCX;Dyskeratosis congenita 1;Dyskeratosis congenita 1 dyskerin;Dyskerin;H/ACA ribonucleoprotein complex subunit 4;NAP 57;NAP57;NOLA 4;NOLA4;Nopp140 associated protein of 57 kDa;Nopp140-associated protein of 57 kDa;Nucleolar protein family A member 4;Nucleolar protein NAP57;snoRNP protein DKC1;XAP 101;XAP101; |
English Name |
Recombinant human DKC1 protein |
Full Name |
dyskeratosis congenita 1,dyskerin |
Chinese Name |
先天性角化不良蛋白1 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
O60832 |
Gene ID |
1736 |
Reactivity |
Human Mouse Rat (Chicken) |
Molecular Weight |
22kDa |
Interval Range |
165-514aa |
Background |
This gene functions in two distinct complexes.It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs).This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion.Mutations have been associated with X-linked dyskeratosis congenita.Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2014] |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |