| Gene Name |
RAB10 |
| Synonyms |
GTP binding protein RAB10;Rab10;RAB10 member RAS oncogene family;RAB10_HUMAN;Ras related GTP binding protein;Ras related GTP binding protein RAB10;Ras-related protein Rab-10; |
| English Name |
Recombinant human RAB10 protein |
| Full Name |
RAB10，member RAS oncogene family |
| Chinese Name |
RAB10,RAS癌基因家族成员 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P61026 |
| Gene ID |
10890 |
| Reactivity |
Human Mouse Rat (Chicken Gorilla) |
| Molecular Weight |
22kDa |
| Interval Range |
1-201aa |
| Background |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164).Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:21248164).That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (PubMed:21248164).Regulates, for instance, SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane (By similarity).In parallel, it regulates the transport of TLR4, a toll-like receptor to the plasma membrane and therefore may be important for innate immune response (By similarity).Plays also a specific role in asymmetric protein transport to the plasma membrane (PubMed:16641372).In neurons, it is involved in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane (By similarity).In epithelial cells, it regulates transport from the Golgi to the basolateral membrane (PubMed:16641372).May play a role in the basolateral recycling pathway and in phagosome maturation (By similarity).May play a role in endoplasmic reticulum dynamics and morphology controlling tubulation along microtubules and tubules fusion (PubMed:23263280).Together with LRRK2, RAB8A, and RILPL1, it regulates ciliogenesis (PubMed:30398148).When phosphorylated by LRRK2 on Thr-73, binds RILPL1 and inhibits ciliogenesis (PubMed:30398148). |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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