| Gene Name |
EIF3I |
| Synonyms |
eIF-3-beta;eIF3 beta;eIF3 p36;eIF3-beta;eIF3-p36;eIF3i;EIF3I_HUMAN;EIF3S2;EIF3S2，formerly;Eukaryotic translation initiation factor 3 subunit 2;Eukaryotic translation initiation factor 3 subunit 2 beta;Eukaryotic translation initiation factor 3 subunit I;eukaryotic translation initiation factor 3，subunit 2 (beta，36kD;eukaryotic translation initiation factor 3，subunit 2 beta，36kDa;eukaryotic translation initiation factor 3，subunit 2，formerly;eukaryotic translation initiation factor 3，subunit I;Predicted protein of HQ2242;PRO2242;TGF beta receptor interacting protein 1;TGF-beta receptor-interacting protein 1;TGFbeta receptor interacting protein 1;TGFbeta receptor-interacting protein 1;TRIP 1;TRIP-1;TRIP1; |
| English Name |
Recombinant human EIF3I protein |
| Full Name |
eukaryotic translation initiation factor 3，subunit I |
| Chinese Name |
真核翻译起始因子亚单位I |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q13347 |
| Gene ID |
8668 |
| Reactivity |
Human Mouse Rat (Bovine Gorilla) |
| Molecular Weight |
36kDa |
| Interval Range |
1-326aa |
| Background |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815).The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition.The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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