| English Name |
Anti-PLK2 Polyclonal Antibody |
| Chinese Name |
polo样蛋白激酶2抗体 |
| Host |
Rabbit |
| Clone Type |
Polyclonal Antibody |
| Subtype |
IgG |
| Predicted Reactivity |
Chimpanzee |
| Dilution Ratio |
WB 1:1000-3000. |
| Target |
PLK2 |
| Synonyms |
hPlk2, hSNK, PLK-2, Plk2, PLK2_HUMAN, Polo like kinase 2, Polo-like kinase 2, Serine/threonine protein kinase PLK2, Serine/threonine protein kinase SNK, Serine/threonine-protein kinase PLK2, Serine/threonine-protein kinase SNK, Serum Induced Kinase, Serum-inducible kinase, SNK |
| Background |
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. |
| Swiss Prot |
Q9NYY3 |
| Gene ID |
10769 |
| Subcellular Location |
Cytoplasm |
| Immunogen |
A synthetic peptide of human PLK2 |
| Public Immunogen Range |
305-355/685aa |
| Calculated MW |
78kDa |
| Purification Method |
Affinity purification |
| Storage Buffer |
PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
| Piece |
Piece |
| Specification |
50ul 100ul |
| Reactivity |
Human Rat Mouse |
| Application |
WB |
English
中文
Manual Download
