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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > IndomethacinCAS：53-86-1
Molecular Formula：C19H16ClNO4
Molecular Weight：357.79
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 53-86-1 |
| Name | Indomethacin |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.79 |
| Solubility | Soluble in DMSO ≥20mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-186-5 |
| MDL | MFCD00057095 |
| SMILES | COC1=CC=C(N(C(C2=CC=C(Cl)C=C2)=O)C(C)=C3CC(O)=O)C3=C1 |
| InChIKey | CGIGDMFJXJATDK-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) |
| PubChem CID | 3715 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Indomethacin is a potent, non-selective COX1 and COX2 inhibitor. |
| Biological Activity | Indomethacin 是一种有效的、非选择性的 COX1 和 COX2 抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 18 nM 和 26 nM。[1-4] |
| Data Literature Source | [1]. Riendeau D，et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Lopes RS，et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [3]. Afroz S，et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. [4]. Qixiong Zhang，et al. Structure-Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities. Chem Mater. 2017，29(19):8221-8238 |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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Huang X, et al. J Cardiovasc Pharmacol. 2022 Jun 1;79(6):904-913.
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