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Cabergoline

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Cat.No：IC3990 Solarbio

CAS：81409-90-7

Molecular Formula：C₂₆H₃₇N₅O₂

Molecular Weight：451.6

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	81409-90-7
Name	Cabergoline
Molecular Formula	C₂₆H₃₇N₅O₂
Molecular Weight	451.6
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 200-419-0
MDL	MFCD00867887
SMILES	C=CCN1[C@](C2C[C@@H](C(N(CCCN(C)C)C(NCC)=O)=O)C1)([H])CC3=CNC4=CC=CC2=C43
InChIKey	KORNTPPJEAJQIU-KJXAQDMKSA-N
InChI	InChI=1S/C26H37N5O2/c1-5-11-30-17-19(25(32)31(26(33)27-6-2)13-8-12-29(3)4)14-21-20-9-7-10-22-24(20)18(16-28-22)15-23(21)30/h5,7,9-10,16,19,21,23,28H,1,6,8,11-15,17H2,2-4H3,(H,27,33)/t19-,21-,23-/m1/s1
PubChem CID	54746
Target Point	Dopamine Receptor
Passage	Neuronal Signaling;GPCR & G Protein
Background	It is a long-acting dopamine agonist and prolactin inhibitor.
Biological Activity	Cabergoline is an ergot derived-dopamine D2-like receptor agonist that has high affinity for D2, D3, and 5-HT2B receptors (Ki=0.7, 1.5, and 1.2, respectively).[1-2]
IC50	Ki: 0.7(Dopamine D2 receptor)，1.5(Dopamine D3 receptor)，1.2(5-HT2B receptor)[1]
Data Literature Source	[1]. Odaka H，et al. Cabergoline，dopamine D2 receptor agonist，prevents neuronal cell death under oxidative stress via reducing excitotoxicity. PLoS One. 2014 Jun 10;9(6):e99271. [2]. Jefferson F，et al. A dopamine receptor d2-type agonist attenuates the ability of stress to alter sleep in mice. Endocrinology. 2014 Nov;155(11):4411-21
Unit	Bottle
Specification	5mg 10mM*1mL in DMSO 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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