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My CartCAS：1051375-19-9
Molecular Formula：C20H18F2N3NaO5
Molecular Weight：443.38
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1051375-19-9 |
| Name | Dolutegravir Sodium |
| Molecular Formula | C20H18F2N3NaO5 |
| Molecular Weight | 443.38 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years |
| EC | EINECS 812-620-6 |
| MDL | MFCD28405599 |
| SMILES | [O-]C(C(C(C(NCC1=CC=C(F)C=C1F)=O)=C2)=O)=C3N2C[C@]4([H])OCC[C@@H](C)N4C3=O.[Na+] |
| Target Point | HIV Integrase |
| Passage | Anti-infection |
| Background | Dolutegravir Sodium is an HIV integrase inhibitor. |
| Biological Activity | Dolutegravir钠盐是HIV蛋白酶强效抑制剂，IC50值为2.7nM，对Raltegravir耐药突变型HIV毒株Y143R, Q148K, N155H,和G140S/Q148H也有一定的抑制作用。[1-2] |
| Data Literature Source | [1]. Kobayashi M，et al. In Vitro antiretroviral properties of S/GSK1349572，a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother. 2011 Feb;55(2):813-21. [2]. Moss L，et al. The comparative disposition and metabolism of dolutegravir，a potent HIV-1 integrase inhibitor，in mice，rats，and monkeys. Xenobiotica. 2015 Jan;45(1):60-70. |
| Unit | Bottle |
| Specification | 1mg 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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