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My CartCAS：142217-69-4
Molecular Formula：C12H15N5O3
Molecular Weight：277.28
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 142217-69-4 |
| Name | Entecavir |
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 604-279-5 |
| MDL | MFCD00907887 |
| SMILES | O=C1NC(N)=NC2=C1N=CN2[C@@H]3C([C@H](CO)[C@@H](O)C3)=C |
| Target Point | HBV |
| Passage | Anti-infection |
| Background | It is a selective and effective HBV inhibitor. |
| Biological Activity | Entecavir（SQ 34676; BMS 200475）是有选择且有效地HBV抑制剂。在HepG2细胞中的EC50值为3.75 nM。[1-3] |
| IC50 | EC50: 3.75nM(anti-HBV，HepG2 cell)[2] |
| Data Literature Source | [1]. Innaimo SF，et al. Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41(7):1444-9. [2]. Rivkin A，et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin. 2005 Nov;21(11):1845-57. [3]. Genovesi EV，et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother. 1998 Dec;42(12):3209-18 |
| Unit | Bottle |
| Specification | 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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