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(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one

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Cat.No：IA5040 Solarbio

CAS：1009817-63-3

Molecular Formula：C₂₂H₁₇N₃O₆

Molecular Weight：419.39

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1009817-63-3
Name	(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one
Molecular Formula	C₂₂H₁₇N₃O₆
Molecular Weight	419.39
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD26142662
SMILES	O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3
Target Point	Deubiquitinase（DUB）
Passage	Ubiquitin
Background	(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one is an inhibitor of deubiquitinases.
Biological Activity	b-AP15 特异性抑制去泛素化酶 (deubiquitinating) UCHL5 和 Usp14活性。[1-3]
Data Literature Source	[1]. D'Arcy P，et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40. [2]. Wang X，et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45. [3]. Tian Z，et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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