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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > 1-AzakenpaulloneCAS：676596-65-9
Molecular Formula：C15 H10 Br N3 O
Molecular Weight：328.16
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 676596-65-9 |
| Name | 1-Azakenpaullone |
| Molecular Formula | C15 H10 Br N3 O |
| Molecular Weight | 328.16 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| MDL | MFCD09037522 |
| SMILES | O=C(NC1=CC=CN=C12)CC3=C2NC4=C3C=C(Br)C=C4 |
| Target Point | GSK-3 |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | 1-Azakenpaullone is a highly selective GSK-3β inhibitor. |
| Biological Activity | 1-Azakenpaullone可选择性抑制CDK1/cyclin B、CDK5/p25和GSK-3β活性, IC50值分别为0.018 μM、 4.2 μM和2.0 μM。[1] |
| Data Literature Source | [1] Kunick C，et al. Bioorg Med Chem Lett. 2004，14(2)，413-416. [2] Liu H，et al. Diabetes. 2009，58(3)，663-672. [3] Stukenbrock H，et al. J Med Chem. 2008，51(7)，2196-2207. [4] Mussmann R，et al. J Biol Chem. 2007，282(16)，12030-12037. [5] Chan MH，et al. Schizophr Res. 2012，136(1-3)，96-103. [6] Leost M，et al. Eur J Biochem. 2000，267(19)，5983-5994. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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