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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > A-66CAS：1166227-08-2
Molecular Formula：C17H23N5O2S2
Molecular Weight：393.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1166227-08-2 |
| Name | A-66 |
| Molecular Formula | C17H23N5O2S2 |
| Molecular Weight | 393.53 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22378485 |
| SMILES | CC(C)(C1=NC(C2=C(N=C(S2)NC(N3[C@@H](CCC3)C(N)=O)=O)C)=CS1)C |
| Target Point | PI3K |
| Passage | PI3K/Akt/mTOR |
| Background | It is a potent and specific p110α inhibitor. |
| Biological Activity | A66 是一种高特异性的选择性的 p110α 抑制剂，IC50 为 32 nM。[1-2] |
| IC50 | p110α:32nM;p110α E545K:30nM;p110α H1047R:43nM;PI3K-C2β:462nM;PI4Kβ:236nM[1-2] |
| Data Literature Source | [1]. Jamieson S，et al. A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types. Biochem J，2011，438(1)，53-62. [2]. Sun M，et al. Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha. Proc Natl Acad Sci U S A，2010，107(35)，15547-15552 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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