Your Position: Home > Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > A-674563

A-674563

Manual Download

Cat.No：IA2820 Solarbio

CAS：552325-73-2

Molecular Formula：C₂₂H₂₂N₄O

Molecular Weight：358.44

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

Qty：

Size：

Add to cart

Product Information Experimental Images Related Products Related Paper Technical Q&A

Product Information

CAS	552325-73-2
Name	A-674563
Molecular Formula	C₂₂H₂₂N₄O
Molecular Weight	358.44
Solubility	Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18711680
SMILES	N[C@@H](CC1=CC=CC=C1)COC2=CC(C3=CC4=C(C=C3)NN=C4C)=CN=C2
Target Point	Akt
Passage	PI3K/Akt/mTOR
Background	A-674563 is an Akt inhibitor.
Biological Activity	A-674563是有效，选择性的 Akt1 抑制剂，Ki为11 nM。[1-5]
Data Literature Source	[1]. Luo Y，et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther，2005，4(6)，977-986. [2]. Zhu QS，et al. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res，2008，68(8)，2895-2903. [3]. Zou Y，et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent. Biochem Biophys Res Commun. 2016 Aug 12;477(1):1-8. [4]. Xu L，et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells. Biochem Biophys Res Commun. 2016 Apr 15;472(4):662-8. [5]. Wang A，et al. Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML. Oncotarget. 2016 May 17;7(20):29131-42.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

Note：

1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.

2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.

3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.