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Alectinib

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Cat.No：IA3080 Solarbio

CAS：1256580-46-7

Molecular Formula：C₃₀H₃₄N₄O₂

Molecular Weight：482.62

Storage：Powder:2-8℃，2 years

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1256580-46-7
Name	Alectinib
Molecular Formula	C₃₀H₃₄N₄O₂
Molecular Weight	482.62
Solubility	Soluble in DMSO ≥0.1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years
EC	EINECS 821-541-6
MDL	MFCD19440988
SMILES	N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1
Target Point	ALK
Passage	Protein Tyrosine Kinase/RTK;Angiogenesis
Background	Alectinib is a potent ALK inhibitor.
Biological Activity	Alectinib (CH5424802) 是一种有效，选择性和可口服的 ALK 抑制剂，IC50 为1.9 nM。[1-4]
IC50	1.9nM(ALK)，1nM(ALKF1174L)，3.5nM(ALKR1275Q)[1] Kd: 2.4nM(ALK)[1]
Data Literature Source	[1]. Sakamoto H，et al. CH5424802，a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant. Cancer Cell. 2011，19(5)，679-690. [2]. Kinoshita K，et al. Design and synthesis of a highly selective，orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802). Bioorg Med Chem. 2012，20(3)，1271-1280. [3]. Kodama T，et al. Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases. Cancer Chemother Pharmacol. 2014 Nov;74(5):1023-8. [4]. Miyazaki M，et al. The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas. Cell Death Discov. 2018 May 10;4:56
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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