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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Allitinib TosylateCAS：1050500-29-2
Molecular Formula：C24H18ClFN4O2·C7H8O3S
Molecular Weight：621.08
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1050500-29-2 |
| Name | Allitinib Tosylate |
| Molecular Formula | C24H18ClFN4O2·C7H8O3S |
| Molecular Weight | 621.08 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | FC1=CC=CC(COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(C=C)=O)C=C4)C=C2)=C1.O=S(C5=CC=C(C)C=C5)(O)=O |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Allitinib Tosylate is an irreversible EGFR and ErbB2 inhibitor. |
| Biological Activity | Allitinib (AST-1306, AST-6) 是一种新型，不可逆的EGFR和ErbB2抑制剂，IC50分别为0.5 nM和3 nM，对突变型EGFR T790M/L858R也有效，作用于过表达ErbB2的细胞更有效，作用于ErbB家族比作用于其他激酶选择性高3000倍。[1] |
| Data Literature Source | 1] Xie H，et al. PLoS One. 2011，6(7)，e21487. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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