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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > A-769662CAS：844499-71-4
Molecular Formula：C20H12N2O3S
Molecular Weight：360.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 844499-71-4 |
| Name | A-769662 |
| Molecular Formula | C20H12N2O3S |
| Molecular Weight | 360.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11977269 |
| SMILES | N#CC1C(C2=C(NC1=O)SC=C2C3=CC=C(C4=CC=CC=C4O)C=C3)=O |
| Target Point | AMPK |
| Passage | PI3K/Akt/mTOR;Epigenetics |
| Background | A-769662 is a potent, reversible AMPK activator. |
| Biological Activity | A-769662 是一种有效的，可逆的 AMPK 激活剂，EC50 值为 0.8 μM。[1-4] |
| Data Literature Source | [1]. Cool B，et al. Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab，2006，3(6)，403-416. [2]. Sanders MJ，et al. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662，a member of the thienopyridone family. J Biol Chem，2007，282(45)，32539-32548. [3]. Moreno D，et al，A769662，a novel activator of AMP-activated protein kinase，inhibits non-proteolytic components of the 26S proteasome by an AMPK-independent mechanism. FEBS Lett，2008，583(17)，2650-2654. [4]. Yerra VG，et al. Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis，Autophagy and Neuroinflammation. Mol Neurobiol. 2017 Apr;54(3):2301-2312. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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