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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > A-804598CAS：1125758-85-1
Molecular Formula：C19H17N5
Molecular Weight：315.37
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1125758-85-1 |
| Name | A-804598 |
| Molecular Formula | C19H17N5 |
| Molecular Weight | 315.37 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C[C@@H](C1=CC=CC=C1)N/C(NC#N)=N\C2=CC=CC3=C2C=CC=N3 |
| Target Point | P2X Receptor |
| Passage | Membrane Transporter&Ion Channel |
| Background | A-804598 is a selective P2X7R antagonist. |
| Biological Activity | A-804598是一种选择性的P2X7R拮抗剂。它对大鼠P2X7受体（IC50 = 10 nM）、小鼠P2X7受体（IC50 = 9 nM）和人源P2X7受体（IC50 = 11 nM）皆具有高亲和力。[1-2] |
| IC50 | 9nM(mouse P2X7 receptor)，10nM(rat P2X7 receptor)，11nM(human P2X7 receptor)[1] |
| Data Literature Source | [1] Donnelly-Roberts DL，et al. Neuropharmacology. 2009，56(1):223-9. [2] Fabbrizio P，et al. Front Cell Neurosci. 2017，11:249. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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