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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > Afatinib DimaleateCAS：850140-73-7
Molecular Formula：C24H25ClFN5O3·2C4H4O4
Molecular Weight：717.18
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 850140-73-7 |
| Name | Afatinib Dimaleate |
| Molecular Formula | C24H25ClFN5O3·2C4H4O4 |
| Molecular Weight | 717.18 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 810-416-1 |
| MDL | MFCD25974239 |
| SMILES | O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O |
| Target Point | EGFR |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | Afatinib Dimaleate is an irreversible EGFR/HER2 inhibitor. |
| Biological Activity | Afatinib dimaleate是不可逆的 EGFR 家族抑制剂，抑制EGFRwt，EGFRL858R，EGFRL858R/T790M 和 HER2的 IC50 分别为0.5 nM，0.4 nM，10 nM 和 14 nM。[1-2] |
| Data Literature Source | [1]. Li D，et al. BIBW2992，an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models. Oncogene. 2008 Aug 7;27(34):4702-11. [2]. Wong CH，et al. Preclinical evaluation of afatinib (BIBW2992) in esophageal squamous cell carcinoma (ESCC). Am J Cancer Res. 2015 Nov 15;5(12):3588-99 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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