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AG-1478

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Cat.No：IA3010 Solarbio

CAS：153436-53-4

Molecular Formula：C₁₆H₁₄ClN₃O₂

Molecular Weight：315.75

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	153436-53-4
Name	AG-1478
Molecular Formula	C₁₆H₁₄ClN₃O₂
Molecular Weight	315.75
Solubility	Soluble in DMSO ≥5mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00270914
SMILES	COC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
InChIKey	GFNNBHLJANVSQV-UHFFFAOYSA-N
InChI	InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
PubChem CID	2051
Target Point	EGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	AG-1478 is a selective EGFR inhibitor.
Biological Activity	AG-1478 是一种选择性的 EGFR 酪氨酸激酶抑制剂，IC50 为 3 nM。[1-3]
Data Literature Source	[1]. Bojko A，et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95. [2]. Li W，et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580. [3]. Akhtar S，et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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