English Name |
Anti-DTX3L Polyclonal Antibody |
Chinese Name |
E3泛素蛋白连接酶DTX3L抗体 |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Dilution Ratio |
IHC 1:50-200. |
Target |
DTX3L |
Synonyms |
B lymphoma and BAL associated protein, B-lymphoma- and BAL-associated protein, BBAP, Deltex 3 like, DTX 3L, DTX3L, DTX3L_HUMAN, E3 ubiquitin-protein ligase DTX3L, Protein deltex 3 like, Protein deltex 3 like protein, Protein deltex-3-like, Rhysin 2, Rhysin-2, Rhysin2 |
Background |
E3 ubiquitin-protein ligase which, in association with ADP-ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses (PubMed:12670957, PubMed:19818714, PubMed:26479788, PubMed:23230272). Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4 (PubMed:28525742). In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1) (PubMed:19818714). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me) (PubMed:19818714). PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272). |
Swiss Prot |
Q8TDB6 |
Gene ID |
151636 |
Subcellular Location |
Cytoplasm Nucleus |
Immunogen |
Recombinant protein of human DTX3L |
Public Immunogen Range |
1-350aa |
Calculated MW |
26/84kDa |
Purification Method |
Octanoic acid-ammonium sulfate precipitation |
Storage Buffer |
PBS with 50% Glycerol,0.03% Proclin300,0.5% BSA,pH 7.3. |
Storage |
Store at -20℃. Avoid freeze/thaw cycles. |
Piece |
Piece |
Specification |
50ul 100ul |
Reactivity |
Human Mouse |
Application |
IHC |