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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > LP-211CAS：1052147-86-0
Molecular Formula：C30H34N4O
Molecular Weight：466.62
Storage：Store at -20℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Oil
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| CAS | 1052147-86-0 |
| Name | LP-211 |
| Molecular Formula | C30H34N4O |
| Molecular Weight | 466.62 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Oil |
| Storage | Store at -20℃，2 years |
| SMILES | C1CN(CCN1CCCCCC(=O)NCC2=CC=C(C=C2)C#N)C3=CC=CC=C3C4=CC=CC=C4 |
| Target Point | 5-HT Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | LP-211 is a selective and blood?brain barrier penetrant 5-HT7 receptor agonist， with a Ki of 0.58 nM， with high selectivity over 5-HT1A receptor (Ki， 188 nM) and D2 receptor (Ki， 142 nM).[1-3] |
| Data Literature Source | Binding of [3H]-LSD at rat cloned 5-HT7 receptor is performed in the assay. In 1 mL of incubation buffer (50 mM Tris， 10 mM MgCl2 and 0.5 mM EDTA， pH 7.4) are suspended 30 μg of membranes， 2.5 nM [3H]-LSD， LP-211 (6?9 concentrations). The samples are incubated for 60 min at 37°C. The incubation is stopped by rapid filtration on GF/A glass fiber filters (presoaked in 0.5% polyethylenimine for 30 min). The filters are washed with 3 × 53 mL of ice-cold buffer (50 mM Tris， pH 7.4). Nonspecific binding is determined in the presence of 10 μM 5-CT. Approximately 90% of specific binding is determined under these conditions[1]. |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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