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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > Larotrectinib SulfateCAS：1223405-08-0
Molecular Formula：C21H22F2N6O2·H2SO4
Molecular Weight：526.51
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 1223405-08-0 |
| Name | Larotrectinib Sulfate |
| Molecular Formula | C21H22F2N6O2·H2SO4 |
| Molecular Weight | 526.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 232-655-5 |
| MDL | MFCD29472286 |
| SMILES | C1C[C@@H](N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CC[C@@H](C4)O)C5=C(C=CC(=C5)F)F.OS(=O)(=O)O |
| Target Point | Trk Receptor |
| Passage | Protein Tyrosine Kinase/RTK;Neuronal Signaling |
| Background | Larotrectinib Sulfate is an ATP-competitive TRK inhibitor. |
| Biological Activity | Larotrectinib sulfate (LOXO-101, ARRY-470)是一种可口服的、选择性的、ATP竞争性的原肌球蛋白受体激酶TRK的有效抑制剂。Larotrectinib 对TRKs的抑制作用可诱导细胞凋亡和G1细胞周期阻滞。[1] |
| Data Literature Source | [1] Ghilardi JR，et al. Mol Pain. 2010，6:87. [2] Vaishnavi A，et al. Nat Med. 2013，19(11):1469-72. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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