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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > AMG-517CAS：659730-32-2
Molecular Formula：C20H13F3N4O2S
Molecular Weight：430.4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 659730-32-2 |
| Name | AMG-517 |
| Molecular Formula | C20H13F3N4O2S |
| Molecular Weight | 430.4 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14584859 |
| SMILES | CC(NC1=NC2=C(OC3=NC=NC(C4=CC=C(C(F)(F)F)C=C4)=C3)C=CC=C2S1)=O |
| Target Point | TRPV |
| Passage | Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | AMG-517 is a potent vanilloid receptor-1 (TRPV1) antagonist. |
| Biological Activity | AMG-517是一种有效的，选择性的TRPV1拮抗剂，抑制TRPV1的Capsaicin， Proton和热激活，IC50分别为0.76 nM， 0.62 nM和1.3 nM。[1-2] |
| Data Literature Source | [1] Gavva NR，et al. J Pharmacol Exp Ther，2007，323(1)，128-137. [2] Gavva NR，et al. Pain，2008，136(1-2)，202-210. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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