{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > ApilimodCAS：541550-19-0
Molecular Formula：C23H26N6O2
Molecular Weight：418.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 541550-19-0 |
| Name | Apilimod |
| Molecular Formula | C23H26N6O2 |
| Molecular Weight | 418.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09954108 |
| SMILES | CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1 |
| Target Point | Interleukin Related |
| Passage | Immunology & Inflammation |
| Background | It is a potent inhibitor of IL-12/IL-23. |
| Biological Activity | Apilimod (STA-5326) 是一种有效的细胞因子 interleukin-12 (IL-12) 和 interleukin-23 (IL-23) 的口服抑制剂，具有治疗某些自身免疫和炎性疾病的潜力。Apilimod (STA-5326) 可抑制IL-12，在IFN-γ/SAC刺激的人PBMC细胞、人单核细胞和小鼠PBMC细胞中，对应的IC50值分别为1 nM、1 nM和2 nM。Apilimod (STA-5326) 也是一种具有细胞通透性的小分子化合物，抑制PIKfyve，IC50为14 nM。[1-2] |
| Data Literature Source | [1] Cai X，et al. Chem Biol. 2013，20(7):912-21. [2] Diego Sbrissa，et al. PLoS One. 2018，13(9): e0204532. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
