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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AvapritinibCAS：1703793-34-3
Molecular Formula：C26H27FN10
Molecular Weight：498.56
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1703793-34-3 |
| Name | Avapritinib |
| Molecular Formula | C26H27FN10 |
| Molecular Weight | 498.56 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31544325 |
| SMILES | CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1 |
| Target Point | c-Kit，PDGFRα |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Avapritinib is a novel, potent, and selective inhibitor of PDGFRα D842V; also an inhibitor of the Kit (c-Kit) mutation (Kit (c-Kit) D816V). |
| Biological Activity | Avapritinib (BLU-285)是一种小分子激酶抑制剂，可有效抑制PDGFRα D842V突变体的活性、在细胞背景下抑制PDGFRα D842V自我磷酸化（IC50=30 nM）；同时也是Kit (c-Kit)突变（Kit (c-Kit) D816V）的抑制剂（IC50=0.5 nM）。[1] |
| IC50 | PDGFRα(D842V): 0.5nM;c-Kit(D816V) : 0.5nM[1] |
| Data Literature Source | [1] Erica K. Evans，et al. AACR Cancer Res. 2015，75(15 Suppl):Abstract nr 791. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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