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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > AZD-1390CAS：2089288-03-7
Molecular Formula：C27H32FN5O2
Molecular Weight：477.57
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2089288-03-7 |
| Name | AZD-1390 |
| Molecular Formula | C27H32FN5O2 |
| Molecular Weight | 477.57 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31619275 |
| SMILES | O=C(N1C(C)C)N(C)C2=C1C3=CC(C4=CC=C(OCCCN5CCCCC5)N=C4)=C(F)C=C3N=C2 |
| Target Point | ATM/ATR |
| Passage | DNA Damage/DNA Repair; PI3K/Akt/mTOR |
| Background | AZD-1390 is an ATM inhibitor. |
| Biological Activity | AZD1390是一种具有口服活性的、能穿透中枢神经系统的ATM抑制剂，在细胞中IC50为0.78 nM。它对ATM的选择性是对PIKK家族其他相关酶的10,000以上，具有良好的选择性。[1-2] |
| Data Literature Source | [1] Kurt G Pike，et al. AACR Mol Cancer Ther. 2018，17(1 Suppl):Abstract nr A124. [2] Stephen T. Durant，et al. Science Advances. 2018，4(6): eaat1 |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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