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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > AZD-2858CAS：486424-20-8
Molecular Formula：C21H23N7O3S
Molecular Weight：453.52
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 486424-20-8 |
| Name | AZD-2858 |
| Molecular Formula | C21H23N7O3S |
| Molecular Weight | 453.52 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26397072 |
| SMILES | O=C(C1=NC(C2=CC=C(S(=O)(N3CCN(C)CC3)=O)C=C2)=CN=C1N)NC4=CC=CN=C4 |
| Target Point | GSK-3 |
| Passage | PI3K/Akt/mTOR;Stem Cells |
| Background | AZD-2858 is a potent GSK-3 inhibitor that inhibits the activities of GSK-3α and GSK-3β. |
| Biological Activity | AZD2858 是一种有效的，可口服的 GSK-3 抑制剂，可以抑制 GSK-3α 和 GSK-3β 的活性，IC50 值分别为 0.9 和 5 nM，可用于骨折愈合的研究。[1-4] |
| Data Literature Source | [1]. Marsell R，et al. GSK-3 inhibition by an orally active small molecule increases bone mass in rats. Bone. 2012 Mar;50(3):619-27. [2]. Sisask G，et al. Rats treated with AZD2858，a GSK3 inhibitor，heal fractures rapidly without endochondral bone formation. Bone. 2013 May;54(1):126-32. [3]. Gilmour PS，et al. Human stem cell osteoblastogenesis mediated by novel glycogen synthase kinase 3 inhibitors induces bone formation and a unique bone turnover biomarker profile in rats. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):399-407. [4]. Gambardella A，et al. Glycogen synthase kinase-3α/β inhibition promotes in vivo amplification of endogenous mesenchymal progenitors with osteogenic and adipogenic potential and their differentiation to the osteogenic lineage. J Bone Miner Res. 2011 Apr;26(4):811-21. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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