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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > AZD-2932CAS：883986-34-3
Molecular Formula：C24H25N5O4
Molecular Weight：447.49
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 883986-34-3 |
| Name | AZD-2932 |
| Molecular Formula | C24H25N5O4 |
| Molecular Weight | 447.49 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25977021 |
| SMILES | O=C(NC1=CN(C(C)C)N=C1)CC2=CC=C(OC3=C4C=C(OC)C(OC)=CC4=NC=N3)C=C2 |
| Target Point | VEGFR-2;PDGFRβ;Flt-3;c-Kit |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | It is a potent multi-targeted kinase inhibitor. |
| Biological Activity | AZD2932是有效的多靶点激酶抑制剂，细胞试验中的抑制VEGFR2，PDGFβ，PDGFβ 和 PDGFβ 的 IC50 值分别为8，4，7，9 nM。[1] |
| IC50 | VEGFR2:8nM;PDGFRβ:4nM;FLT3:7nM;c-Kit:9nM[1] |
| Data Literature Source | [1]. Plé PA，et al. Discovery of AZD2932，a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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