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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AZD-3463CAS：1356962-20-3
Molecular Formula：C24H25ClN6O
Molecular Weight：448.95
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
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| CAS | 1356962-20-3 |
| Name | AZD-3463 |
| Molecular Formula | C24H25ClN6O |
| Molecular Weight | 448.95 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | ClC(C=NC(NC1=C(OC)C=C(N2CCC(N)CC2)C=C1)=N3)=C3C4=CNC5=C4C=CC=C5 |
| Target Point | IGF-1R，ALK |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | AZD-3463 is an ALK/IGF1R inhibitor. |
| Biological Activity | AZD3463是一种新型的，有效的 ALK 抑制剂，Ki为0.75 nM，也等效抑制 IGF1R。AZD3463 可通过诱导细胞凋亡和自噬来抑制细胞活力。[1-2] |
| Data Literature Source | [1] 104th AACR meeting，2013，Abst 919. [2] Christabel Wilson，et al. Scientific Reports. 2017，7:13955. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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