| Gene Name |
ATF1 |
| Synonyms |
EWS-ATF1;FUS/ATF-1;TREB36;Activating transcription factor 1;ATF 1;atf1;ATF1 EWS fusion gene;ATF1 FUS fusion gene;ATF1_HUMAN;cAMP dependent transcription factor 1;cAMP-dependent transcription factor ATF-1;Cyclic AMP dependent transcription factor ATF 1;Cyclic AMP dependent transcription factor ATF1;Cyclic AMP-dependent transcription factor ATF-1;EWS AFT1;FUS ATF 1;FUS/ATF 1;Protein TREB36;RNA binding protein activating transcription factor 1 fusion protein;TREB 36;TREB36;TREB36 protein |
| English Name |
Recombinant human ATF1 protein |
| Full Name |
activating transcription factor 1 |
| Chinese Name |
激活转录因子1 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 2-7 days， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P18846 |
| Gene ID |
466 |
| Reactivity |
Human Mouse (Bovine) |
| Molecular Weight |
29kDa |
| Interval Range |
1-272aa |
| Background |
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 10μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
No activity experimental data, to be verified. |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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