Gene Name |
CYP3A4 |
Synonyms |
CP33;CP34;CYP3A;CYP3A3;CYP3A4;CYPIIIA4;Cytochrome P450 3A4;Cytochrome P450 family 3 subfamily A polypeptide 4;Cytochrome P450 subfamily IIIA polypeptide 3;Cytochrome P450 subfamily IIIA polypeptide 4;cytochrome P450,family 3,subfamily a,polypeptide 1;glucocorticoid inducible P450;HLP;MGC126680;NF 25;NF25;Nifedipine oxidase;Niphedipine oxidase;P450 III steroid inducible;P450 PCN(PCNC inducible);P450 PCN1;P450C3;P450PCN1;Quinine 3 monooxygenase;Taurochenodeoxycholate 6 alpha hydroxylase;CP3A4_HUMAN |
English Name |
Recombinant human CYP3A4 protein |
Full Name |
cytochrome P450,family 3,subfamily A,polypeptide 4 |
Chinese Name |
细胞色素P450家族3A亚家族多肽4 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
Q6GRK0 |
Gene ID |
1576 |
Reactivity |
Human |
Molecular Weight |
29kDa |
Interval Range |
250-504aa |
Background |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide. |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |