Gene Name |
BACE1 |
Synonyms |
APP beta secretase;Asp 2;ASP2;Aspartyl protease 2;BACE 1;BACE;BACE1;BACE1_HUMAN;Beta secretase 1;Beta secretase;Beta site amyloid beta A4 precursor protein cleaving enzyme;Beta site amyloid precursor protein cleaving enzyme 1;Beta site amyloid precursor protein cleaving enzyme;Beta site APP cleaving enzyme 1;Beta site APP cleaving enzyme;Beta-secretase 1;Beta-site amyloid precursor protein cleaving enzyme 1;Beta-site APP cleaving enzyme 1;FLJ90568;HSPC104;Memapsin 2;Memapsin-2;Memapsin2;Membrane associated aspartic protease 2;Membrane-associated aspartic protease 2;Transmembrane aspartic proteinase Asp2 |
English Name |
Recombinant human BACE1 protein |
Full Name |
beta-site APP-cleaving enzyme 1 |
Chinese Name |
β位点APP裂解酶1 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P56817 |
Gene ID |
23621 |
Reactivity |
Human Mouse Rat (Bovine) |
Molecular Weight |
38kDa |
Interval Range |
6-347aa |
Background |
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (PubMed:10656250, PubMed:10677483, PubMed:20354142).Cleaves CHL1 (By similarity). |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |