| Gene Name |
PSTPIP1 |
| Synonyms |
CD2 antigen binding protein 1;CD2 binding protein 1;CD2 cytoplasmic tail binding protein;CD2-binding protein 1;CD2BP1;CD2BP1L;CD2BP1S;H PIP;H-PIP;HPIP;PAPAS;PEST phosphatase interacting protein 1;PEST phosphatase-interacting protein 1;PPIP1_HUMAN;Proline serine threonine phosphatase interacting protein 1;Proline-serine-threonine phosphatase-interacting protein 1;PSTPIP;Pstpip1 |
| English Name |
Recombinant human PSTPIP1 protein |
| Full Name |
proline-serine-threonine phosphatase interacting protein 1 |
| Chinese Name |
脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白1 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
O43586 |
| Gene ID |
9051 |
| Reactivity |
Human Mouse |
| Molecular Weight |
48kDa |
| Interval Range |
1-417aa |
| Background |
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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