| Gene Name |
HLA-DRA |
| Synonyms |
CD;CELIAC 1;CELIAC1;DP beta 1 chain;DP(W4) beta chain;DPB1;DPB1_HUMAN;DQ A1;DRB1;DRB4;FLJ27088;FLJ27328;GSE;HLA class II histocompatibility antigen;HLA class II histocompatibility antigen DR 1 beta;HLA class II histocompatibility antigen DR alpha;HLA class II histocompatibility antigen DR alpha chain;HLA DP histocompatibility type beta 1 subunit;HLA DP1B;HLA DPB1;HLA DQA;HLA DQA1;HLA DQB;HLA DQB1;HLA DR1B;HLA DR3B;HLA DR4B;HLA DRA;HLA DRA1;HLA DRB1;HLA DRB3;HLA DRB4;HLA DRB5;HLA-DPB1;IDDM 1;IDDM1;Major histocompatibility complex class II DP beta 1;Major histocompatibility complex class II DQ alpha 1;Major histocompatibility complex class II DQ beta 1;Major histocompatibility complex class II DR alpha;Major histocompatibility complex class II DR beta 1;Major histocompatibility complex class II DR beta 3;Major histocompatibility complex class II DR beta 4;Major histocompatibility complex class II DR beta 5;MGC117330;MHC class II antigen DPB1;MHC class II antigen DRA;MHC class II HLA DQ alpha 1;MHC class II HLA DR beta 1;MHC class II HLA DR beta 3;MHC DPB1;MHC DQ beta;MHC HLA DPB1;MHC HLA DQ alpha |
| English Name |
Recombinant human HLA-DRA protein |
| Full Name |
major histocompatibility complex，class II，DR alpha |
| Chinese Name |
主要组织相容性复合体II类DRα |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
P01903 |
| Gene ID |
3122 |
| Reactivity |
Human |
| Molecular Weight |
25kDa |
| Interval Range |
1-215aa |
| Background |
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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