| Gene Name |
IFIH1 |
| Synonyms |
CADM-140 autoantigen;Clinically amyopathic dermatomyositis autoantigen 140 kDa;DEAD/H (Asp Glu Ala Asp/His) box polypeptide;DEAD/H box polypeptide;Helicard;Helicase with 2 CARD domains;Hlcd;IDDM 19;IDDM19;IFIH 1;Ifih1;IFIH1_HUMAN;Interferon induced helicase C domain containing protein 1;interferon induced with helicase C domain 1;Interferon induced with helicase C domain protein 1;Interferon-induced helicase C domain-containing protein 1;Interferon-induced with helicase C domain protein 1;MDA 5;MDA-5;Melanoma differentiation associated protein 5;Melanoma differentiation-associated gene 5;Melanoma differentiation-associated protein 5;MGC133047;Murabutide down regulated protein;Murabutide down-regulated protein;RH 116;RH116;RIG I like receptor 2;RLR 2;RNA helicase DEAD box protein 116;RNA helicase-DEAD box protein 116 |
| English Name |
Recombinant human IFIH1 protein |
| Full Name |
interferon induced with helicase C domain 1 |
| Chinese Name |
含干扰素诱导解旋酶C域蛋白1 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q9BYX4 |
| Gene ID |
64135 |
| Reactivity |
Human Mouse |
| Molecular Weight |
25kDa |
| Interval Range |
1-222aa |
| Background |
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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