| Gene Name |
CHMP5 |
| Synonyms |
apoptosis-related protein PNAS-2 ;C9orf83 ;CGI 34 ;Charged multivesicular body protein 5 ;CHMP 5 ;CHMP family，member 5 ;chmp5 ;CHMP5_HUMAN ;Chromatin modifying protein 5 ;Chromatin-modifying protein 5 ;Chromosome 9 open reading frame 83 ;HGNC:26942 ;HSPC177 ;hVps60 ;PNAS 2 ;SNF7 domain containing protein 2 ;SNF7 domain-containing protein 2 ;SNF7DC2 ;Vacuolar protein sorting 60 ;Vacuolar protein sorting-associated protein 60 ;Vps60 |
| English Name |
Recombinant human CHMP5 protein |
| Full Name |
chromatin modifying protein 5 |
| Chinese Name |
染色质修饰蛋白5 |
| Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
| Purity |
≥85% by SDS-PAGE. |
| Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks， stored at < -20℃ for 1 year. |
| Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
| Concentration |
1mg/ml by SDS-PAGE. |
| Swiss Prot |
Q9NZZ3 |
| Gene ID |
51510 |
| Reactivity |
Human Mouse Rat (Zebrafish Orangutan) |
| Molecular Weight |
24kDa |
| Interval Range |
1-220aa |
| Background |
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release. |
| Application |
Immunology research |
| Source |
E.coli |
| Purification Method |
NI-NTA affinity purification |
| Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
| Endotoxin |
Not measured |
| Biological Activity |
N0 |
| Lable Information |
With a 6×His tag at the N/C-terminus. |
| Unit |
Piece |
| Specification |
10ug 50ug 100ug 1mg |
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