Gene Name |
SHC1 |
Synonyms |
FLJ26504;p66;p66SHC;SH2 domain protein C1;SHC (Src homology 2 domain containing) transforming protein 1;SHC 1;SHC A;SHC adaptor protein 1;Shc;SHC transforming protein 1;SHC transforming protein;SHC-transforming protein 1;SHC-transforming protein 3;SHC-transforming protein A;SHC1;SHC1_HUMAN;SHCA;Src homology 2 domain-containing-transforming protein C1 |
English Name |
Recombinant human SHC1 protein |
Full Name |
SHC (Src homology 2 domain containing) transforming protein 1 |
Chinese Name |
SHC(Src同源2结构域)转化蛋白1 |
Appearance |
Powder: Lyophilized from a 0.2 μm filtered solution of 2-8M Urea, 20mM Tris-HCl, 150mM NaCl, 1mM DTT, PH7.2-8.0. |
Purity |
≥85% by SDS-PAGE. |
Storage |
Reconstituted protein solution can be stored at 4-7℃ for 1-2 weeks, stored at < -20℃ for 1 year. |
Transport Condition |
The product is shipped at -20℃ temperature. Upon receipt, store it immediately at the temperature listed below. |
Concentration |
1mg/ml by SDS-PAGE. |
Swiss Prot |
P29353 |
Gene ID |
6464 |
Reactivity |
Human Mouse Rat (Bovine Orangutan) |
Molecular Weight |
39kDa |
Interval Range |
125-474aa |
Background |
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011] |
Application |
Immunology research |
Source |
E.coli |
Purification Method |
NI-NTA affinity purification |
Solvent |
Reconstituted protein solution can be diluted with distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. (It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water.) |
Endotoxin |
Not measured |
Biological Activity |
N0 |
Lable Information |
With a 6×His tag at the N/C-terminus. |
Unit |
Piece |
Specification |
10ug 50ug 100ug 1mg |